A fertility and general reproductive ability study was performed in Sprague-Dawley rats subcutaneous injected with LBD-009(Lucky, Co Ltd.: Human Growth Hormone) at dose levels 1, 3 and 10IU/kg, Male rats were treated with LBD-009 from 60days
before
mating until 7days after delivery. Female rats received from 14 days before mating until 7 days after delivery. No significant external, viscera, and skeletal anomalies or mental and physical development attributable to treatment was noted in any
fetuses examined. The fertility of F1 generation was not affected by the treatment also.
Thus, LBD-009 has no harmful effect on mating, fertilization, implantation, embryonic development and normal physical development.
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